Molecular docking analysis of Indole based oxadiazoles with the H-binding protein from Treponema denticola

Treponema denticola is a gram-negative bacteria that associated with periodontal diseases. Literature derived, six indole based oxadiazole derivatives are docked the target Factor H binding protein (fHbp) protein. Results show better docking interaction compared to clinically proven drugs and all compounds obey Lipinski’s rule of five. Hence, were inferred be potential inhibitors for factor denticola.